WEIGHT LOSS INJECTIONS
SEMAGLUTIDE & TIRZEPATIDE; WHAT ARE THEY?
Semaglutide is a medication used to treat type 2 diabetes. It belongs to a class of drugs called glucagon-like peptide-1 (GLP-1) receptor agonists. It works to slow the movement of food from the stomach into the small intestine. As a result, you may feel full faster and longer, so you eat less.
Semaglutide helps control blood sugar levels by increasing insulin production and reducing the amount of glucose produced by the liver.
Tirzepatide is another GLP-1 RA, and acts similarly but it also has a dual action. Tirzepatide simultaneously acts on the glucose-dependent insulinotropic polypeptide (GIP) receptor. GIP is another hormone involved in regulating blood sugar levels after eating. By targeting both GLP-1 and GIP receptors, tirzepatide is designed to provide more effective weight loss.
WHAT IS THE DIFFERENCE BETWEEN THE TWO?
They are very similar drugs, used for the same conditions. Tirzepatide is a newer and slightly more effective GLP-1 for weight loss. However, it is also more expensive. We generally recommend patients start on Semaglutide to save money. If Patients max-out on their Semaglutide dosing and have not yet reached their target weight, we will recommend switching to Tirzepatide.
HOW DO THEY HELP YOU LOSE WEIGHT?
Semaglutide and Tirzepatide both produce amazing weight loss results by altering your digestive process and helping to minimize food cravings. They work in the following ways:
Increased sensation of feeling full: Semaglutide acts on the GLP-1 receptors in the brain, (hypothalamus) which regulates appetite and feelings of fullness. It induces a feelings of fullness, leading to reduced appetite and decreased food intake.
Slower Gastric Emptying: GLP-1 receptor agonists like semaglutide also slow down the rate at which the stomach empties its contents into the small intestine. This delay in gastric emptying can contribute to increased feelings of fullness and prolonged satisfaction after eating, further reducing food consumption.
Reduced Caloric Intake: The combination of increased satiety and slowed gastric emptying results in a decreased desire to eat, and a lower intake of calories overall.
Weight Set Point Regulation: Semaglutide may also have an impact on the body’s weight set point—the weight range that the body tends to maintain. By influencing the body’s regulatory systems, semaglutide helps shift the weight set point to a lower level, making it easier for some individuals to lose weight and maintain the new lower weight.
AM I A GOOD CANDIDATE FOR WEIGHT LOSS INJECTIONS?
Do you have a BMI of 30 or higher or greater than 27 with other health concerns? If you've been struggling to shed excess pounds and your Body Mass Index (BMI) is appropriate for therapy, Semaglutide could be the key to reaching your weight loss goals. Do you not meet the BMI criteria but still interested in losing weight? Schedule a free consultation to discuss further!
Are you committed to a healthy Lifestyle: Semaglutide is most effective when combined with a balanced diet and regular exercise. If you are dedicated to making sustainable lifestyle changes, this could be the missing piece to your weight loss puzzle.
Do you have persistent weight management challenges: If traditional weight loss methods have fallen short, Semaglutide offers a novel approach to help you achieve and maintain a healthier weight.
WHO SHOULD NOT USE THESE MEDICATIONS?
Persons with a Personal or Family History of Medullary Thyroid Carcinoma (MTC):
Semaglutide may increase the risk of MTC, a rare type of thyroid cancer. Individuals with a personal or family history of MTC or those with Multiple Endocrine Neoplasia syndrome type 2 (a genetic condition associated with MTC) are generally advised against using semaglutide.
Persons with Known Hypersensitivity or Allergic Reaction to Semaglutide:
Individuals who have had a previous allergic reaction or hypersensitivity to semaglutide or any of its components should not use the medication.
Persons with Severe Gastrointestinal Disease:
Semaglutide can cause gastrointestinal side effects such as nausea and vomiting. Individuals with a history of severe gastrointestinal disease may have an increased risk of complications and may need to avoid using semaglutide.
Persons with Pancreatitis:
If an individual has a history of pancreatitis or has a known predisposition to pancreatitis, the use of semaglutide may not be recommended due to the potential risk of exacerbating this condition.
Persons with Severe Renal Impairment or End-Stage Renal Disease:
There may be limitations on the use of semaglutide in individuals with severe renal impairment or end-stage renal disease. Dose adjustments or alternative treatment options may be considered.
Women who are Pregnant or Breastfeeding:
The safety of semaglutide during pregnancy and breastfeeding is not well-established. Healthcare providers may weigh the potential benefits against the risks when considering the use of semaglutide in pregnant or breastfeeding individuals.
It's crucial for individuals considering or using semaglutide to have a thorough discussion with their healthcare provider regarding their medical history, potential contraindications, and the overall suitability of semaglutide for their specific health condition. Always follow the guidance provided by healthcare professionals and refer to the most recent prescribing information for the specific medication.
RISKS ASSOCIATED WITH THEIR USE:
Hypoglycemia (Low Blood Sugar):
Semaglutide, when used in combination with other diabetes medications, may increase the risk of low blood sugar. It's important to monitor your blood sugar levels regularly, especially if you are also taking insulin or sulfonylureas.
Gastrointestinal Issues:
Some patients may experience nausea, vomiting, diarrhea, or constipation. These side effects are usually mild and temporary. If they persist or become severe, contact your healthcare provider.
Pancreatitis:
There have been rare reports of pancreatitis (inflammation of the pancreas) with the use of semaglutide. Inform your healthcare provider immediately if you experience persistent severe abdominal pain.
Thyroid C-Cell Tumors:
Studies in animals have shown an increased risk of thyroid C-cell tumors with semaglutide. It's unclear if this risk applies to humans. Inform your healthcare provider if you or a family member has a history of medullary thyroid carcinoma (MTC).
Hair loss:
There’s no evidence that semaglutide directly causes hair loss. But hair loss can develop with rapid weight loss due to hormonal changes.To avoid this side effect, we start slow and progress slow.
Other:
Other side effects include: Fatigue, dizziness, light headedness. It is recommended to also receive B12 injections with semaglutide (these are discounted for weight loss clients).
Allergic Reactions:
Severe allergic reactions to semaglutide are rare but can occur. Seek medical attention if you experience symptoms such as rash, itching, severe dizziness, or swelling of the face, tongue, or throat.
IMPORTANT SAFETY TIPS
Take semaglutide or Tirzepatide exactly as prescribed by your healthcare provider.
Inform your healthcare provider about all medications you are taking, including over-the-counter drugs and supplements.
Attend regular follow-up appointments to monitor your response to the medication.
WHEN TO CONTACT YOUR HEALTHCARE PROFESSIONAL
Emergency Situations:
Severe allergic reactions
Symptoms of pancreatitis (persistent severe abdominal pain)
Non-Emergency Situations:
Persistent or severe gastrointestinal issues
Concerns about low blood sugar levels